ANALYSIS OF THE PATTERN OF ADVERSE DRUG REACTIONS AT A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY

Virendra Kushwaha*, Pooja Agrawal, Anuj Kumar, Pradeep Kumar, BK Shoraisham and Sarthak Goel

ABSTRACT

Background: Adverse drug reaction (ADR) contributes to drug-related morbidity and mortality, and increases the economic burden of the country. It is important to monitor the effects of drugs, both intended and unwanted, to get an evidence-based assessment of risk / benefit ratio. Today it is well recognized that a reliable Pharmacovigilance system is essential for rational, safe and cost-effective use of medicines and therefore has clear advantages in relation to cost for public health. Aims and Objectives: Evaluation of ADRs in various departments of a tertiary care government hospital. Methodology: A cross-sectional observational study was carried out for a duration of 4 weeks from 16 February 2023 to 15 March 2023. The ADRs were reported from patients attending out-patient department (OPD) and in-patient department (IPD), LLR Hospital of GSVM Medical college. ADR data was collected in a suspected ADR reporting form. Result: During the study period a total of 270 patients were observed in which 107 patients (39.62%) reported ADRs from different departments. Most of the patients were between 21 to 40 years old with male preponderance. The majority of ADRs are of Type–-A (81.30%) while the remaining are of Type-B (15.88%) and Type-C (2.80%). The most frequently involved organ system was GIT (28.97%) followed by CNS, Skin, Renal, Respiratory, CVS, and others. Conclusion: From the study, we conclude that most of the ADRs of type-A of mild severity and preventable, and GIT is the most common system affected. Careful attention is needed in monitoring and reporting of ADR‟s.

Keywords: ADR, OPD, IPD, Pharmacovigilance.