FORMULATION AND EVALUATION OF CILINIDIPINE FLOATING TABLETS
Katika Harika*, Dr. A. Yasodha and Dr. D. Avinash
ABSTRACT
The main objective of the present study was to develop floating formulation containing 250 mg of Cilinidipine for twice therapy using natural polymers like xanthan gum and guar gum. GRDDS improved the bioavailability and therapeutic efficiency of drug. The formulations were prepared by direct compression method. The angle of repose values for formulations ranges from 25.04±0.02 to27.10 ±0.06. Bulk and tapped densities were used for the measurement of compressibility index. The bulk and tapped values for formulations range from 0.25±0.05 to 0.33±0.04 and 0.32±0.04 to 0.38±0.02 respectively the car’s index and harusner’s ratio values for formulations range from 1.05±0.03 to 1.37±0.05 respectively. Thus, all formulations exhibited good flow characteristics. Compared to all formulations F4 showed the best buoyancy lag time, the buoyancy lag time for F4 was found to be 45sec. Total floating time of all formulations was found to be >8 hrs. The formulation containing xanthan gum shows the higher swelling compared to that of the formulations containing both xanthan and guar gum alone. From the above study, concluded that F4 was the optimized formulation which has shown better buoyancy time 45sec and drug release 99.80% in 8hrs. However, further invivo studies can be carried out to support the results. The overall results explained that the tablets prepared by combination of xanthan gum and guar gum could be more effective on floating tablets and has shown more sustained effect than floating tablets containing natural polymer alone.
Keywords: Formulation, Evaluation, Cilinidipine, Floating Tablets.
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