EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

A COMPREHENSIVE META-ANALYSIS OF ALDH1 IMMUNOHISTOCHEMICAL MARKER FOR BREAST CANCER STEM CELLS

Dr. Sharique Ahmad* and Pushpendra D. Pratap

ABSTRACT

Breast carcinoma, a multifaceted and heterogeneous disease, poses a formidable challenge in healthcare, demanding a profound understanding of its biology, progression, and therapeutic potential. This comprehensive meta-analysis embarks on a journey to explore the realm of identifying and targeting breast cancer stem cells (CSCs) by ALDH1 immunohistochemistry (IHC) marker. Our analysis also delves into several others markers, including the well-studied Aldehyde dehydrogenase 1 (ALDH1), CD44/CD24, Epithelial Cell Adhesion Molecule (EpCAM), and Prominin-1 (CD133). With a systematic review of the literature, our objective is to provide a nuanced and comprehensive understanding of these markers, their clinical significance, potential as prognostic indicators, and utility as therapeutic tools. This analysis underscores the need for personalized approaches to breast carcinoma management, recognizing the diverse subtypes and inherent heterogeneity within this complex disease.

Keywords: Breast carcinoma, Cancer stem cells, prognostic indicators, ALDH1.

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