FORMULATION AND CHARECTERIZATION OF ARTEMISININ LIPOSOMES
Dr. H. Padmalatha*, B. Ramcharan Reddy, B. Venkatesh, C. Ajay Kumar, H. Vishnu Kumar and M. Srinu
The active pharmaceutical ingredient Artemisinin was evaluated for its Organoleptic properties and solubility. The results obtained were satisfactory. Artemisinin liposomes were prepared by solvent evaporation, followed by hydration with water and the Phosphatidyl choline concentrations were optimized by various trials.In the present study liposomes containing Artemisinin was prepared. The effect of increase in Phosphatidyl choline concentration in various parameters like particle size, zeta potential and in vitro release profile were studied. The Artemisinin liposomes were formulated and evaluated for its drug content, entrapment efficiency, particle size analysis, zeta potential and invitro drug release profile. Based on the results of Artemisinin liposomes formulations (AL-1- AL-5) formulation AL-5 was selected as the best formulation in which the particle size was 252. 4 nm and the entrapment was 88. 76%. The in vitro % drug release of AL-5 formulation was 98. 54 % and it was found to be suitable formulation for the treatment of Malaria. Hence it can be concluded that the newly formulated controlled release liposomal drug delivery systems of Artemisinin may be ideal and effective in the treatment of Malaria by allowing the drug to release continuously for 24 hrs.
Keywords: Formulation, Charecterization, Artemisinin, Liposomes.
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