EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

DESIGN, PREPARE AND IN-VITRO EVALUATION OF PACLITAXEL MICROSPHERES

Vinay Kumar*, K. Prathibha, Dr A. Yashodha and K. Jyothi

ABSTRACT

Paclitaxel is an orally-administered chemotherapeutic agent used in the treatment of breast cancer. The present research was to formulate and optimize Paclitaxel-loaded microspheres targeting to enhance bioavailability, reduce dose, minimize side effect, and sustain drug release. The Paclitaxel chitosan microspheres were prepared by by Ionotropic gelation technique method.. The drug-excipient compatibility study of active drug (Paclitaxel) and polymer (chitosan) performed by Fourier transform-infrared spectroscopy and differential scanning calorimetry confirmed that there was no interaction. The resulting microspheres were evaluated for partial size, surface morphology, of Paclitaxel microspheres. Formulation F4 showed the maximum entrapment efficiency. Formulation F-4 showed percent entrapment efficiency of 94.60%. Percent yield value was found to be 80.42%. The particle size was found 145.21 μm A sustained release pattern was obtained from the microsphere and the drug‟s bioavailability was found to be enhanced. In vitro release study showed that Paclitaxel release from both kinds of microspheres was slow followed by an increase to reach a maximum of 95.30%.

Keywords: Paclitaxel, FTIR studies, sodium alginate, Ionotropic gelation technique, In vitro drug release studies.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia