DESIGN, PREPARE AND IN-VITRO EVALUATION OF PACLITAXEL MICROSPHERES
Vinay Kumar*, K. Prathibha, Dr A. Yashodha and K. Jyothi
Paclitaxel is an orally-administered chemotherapeutic agent used in the treatment of breast cancer. The present research was to formulate and optimize Paclitaxel-loaded microspheres targeting to enhance bioavailability, reduce dose, minimize side effect, and sustain drug release. The Paclitaxel chitosan microspheres were prepared by by Ionotropic gelation technique method.. The drug-excipient compatibility study of active drug (Paclitaxel) and polymer (chitosan) performed by Fourier transform-infrared spectroscopy and differential scanning calorimetry confirmed that there was no interaction. The resulting microspheres were evaluated for partial size, surface morphology, of Paclitaxel microspheres. Formulation F4 showed the maximum entrapment efficiency. Formulation F-4 showed percent entrapment efficiency of 94.60%. Percent yield value was found to be 80.42%. The particle size was found 145.21 μm A sustained release pattern was obtained from the microsphere and the drug‟s bioavailability was found to be enhanced. In vitro release study showed that Paclitaxel release from both kinds of microspheres was slow followed by an increase to reach a maximum of 95.30%.
Keywords: Paclitaxel, FTIR studies, sodium alginate, Ionotropic gelation technique, In vitro drug release studies.
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