EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

DEVELOPMENT AND CHARACTERIZATION OF THE BACLOFEN-LOADED MICROSPHERES

Sachin Shrivastav, Vaishali Rajput, Kapil Kumar*, Ikram, Aparna Joshi

ABSTRACT

The microsphere can act as a promising choice for conventional parenteral dosage forms. Microspheres are more stable, biocompatible, and easy to administer. This research article is aimed at the formulation and evaluation of the Baclofen microspheres. In this study, the solvent evaporation method was used to manufacture sustained release baclofen Microspheres. Baclofen Microspheres could be a potential drug delivery technique for oral baclofen administration with a 12-hour drug release, according to the findings. With a high percentage of drug entrapment and a high recovery yield, the formulation was determined to be successful. In FT-IR tests, no notable drug interactions were detected. Baclofen microspheres are a promising pharmaceutical dosage form because they allow long-acting medication administration while avoiding dose-related side effects. Out of all the formulations evaluated, microspheres containing F-5 had the maximum drug release at the 12th hour, with 89.83 0.21 percent. The F5 formulation's diffusion has non-fiction zero order kinetics and fits into the Korsmeyer-Peppas model. The baclofen microspheres (F5) formulation was finished successfully. There is less dose dumping because the medicine is released over a longer period, up to 12 hours.

Keywords: In-situ, Sustained release, Microspheres.


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