EVALUATION OF ANTI-ULCER ACTIVITY OF RHODODENDRON ARBORETUM LEAVES ON EXPERIMENTAL ANIMALS
Aale Mohammand*, Praveen Kumar and Dr. Shamim Ahmed
Introduction: Ulcers can grow on the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Peptic ulcers are another term for both types of ulcers. It affects nearly 10% of the global population. Aim: Evaluation of anti-ulcer activity of Rhododendron arboretum leaves on experimental animals. Materials and Methods: This study used ethanol-caused ulcer and swimming stress-induced ulcer models in wistar rats. An ethanolic extract's antiulcer activity (200, and 400 mg/kg p.o. for 7 days) was compared to that of a reference drug (Pantoprazole). Gastric volume, pH, total acidity, free acidity, and ulcer index were the parameters studied in the Ethanol induce ulcer and Pylorus ligation induced Gastric ulcers models, whereas ulcer severity is assessed in the ethanol induce ulcer and Swimming stress induced ulcer models. The criteria studied were ulcer index, gastric juice volume, pH, free acidity, and total acidity. Results: When ethanolic extract treatment groups were associated to ulcer-control groups, the volume of ulcer index, stomach volume, pH of gastric juice, total and free acidity activity were significantly reduced at p<0.05 and p<0.01, respectively. When compared to the ulcer control group, all dosages of Rhododendron arboretum L displayed dose dependent antiulcer efficacy as well as a significant (p<0.05 and p<0.01) reduction in the ulcer index in all experimental models. Conclusion: The outcomes of the study indicate that the ethanolic extract of Rhododendron arboretum has more anti-ulcer power, providing validity to folkloric medicine's conventional claims.
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