A REVIEW ON TELOMERIC DYSFUNCTION
Jyothi Johnson*, Karthika Santhosh, Kripa Kochukunju, Diljit S. Kuttoor and Dr. Elessy Abraham
Telomeres are specialized DNA-protein structures located at the ends of eukaryotic chromosomes whose length is progressively reduced in most somatic cells during ageing. Over the past decade, emerging evidence has shown that the telomeres are essential regulators of cellular life span and chromosome integrity in a dynamic fashion. By inducing genomic instability, replicative senescence and apoptosis, shortening of telomeres is thought to contribute to organismal ageing.In this review aims the role of telomerase of oncogenisis and the diseases associated with telomeric dysfunction.
Keywords: Telomeres, Telomerase, Dyskeratosis congenita, Telomeropathies.
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