LIQUISOLID COMPACTS: A COMPREHENSIVE REVIEW

Vaishnavi Bakka*

ABSTRACT

Solubility is the main Criteria for dissolution and bio availability. Most of the Drug entities are lipophilic in nature and are poorly water soluble. There are several techniques which are used to increase the solubility of water insoluble drugs. Some of the techniques are Nanonization, Complex formation using Cyclodextron, self-emulsifying systems, use of surfactants, use of salt forms, solid dispersion, Micronization etc. Liquisolid compact is one such novel technique used to formulate the poorly water-soluble drugs by using appropriate non-volatile solvents, carrier material, coating material, and disintegrant into free-flowing compressible powder. These free-flowing powders are subjected to compression for tablet or filled in capsules. Liquid solid compacts are also known as ―Powder solution technology‖. The advantages of liquid solid compacts and their wide applications makes it a promising technology.

Keywords: Liquisolid compacts, carrier material, coating material, non-volatile solvents, bioavailability, dissolution.