( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Riham Khaddour*, Faisal Radwan and Malek Hejazie


Background: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global health crisis that has affected populations and spread worldwide. It is clear whether outcome is modulated by serum levels of D-dimer and PCT, in which elevated levels of them are associated with poor outcome. Aim: The purpose of this study was to evaluate the role of D. dimer and PCT as potential predictors for COVID-19 induced fatal clinical complications in hospitalized patients. Materials and Methods: This was an Analytic Cohort study (Retrospective) involved 601 patients with confirmed diagnosis of COVID-19 admitted to quarantine unit, Tishreen University Hospital, Latakia. Patients were divided into two groups according to the levels of PCT and D-dimer, and final outcome was compared between groups. Results: Out of 601 patients, 359 were males and 242 were females, with mean age of the patients 63.08±14.2. D-dimer levels > 985 mg/L were detected in 342 cases, and PCT levels > 0.54 ng/ml in 43 cases, without the presence of significant differences between groups regarding of age and gender (p>0.05). Elevated levels of D-dimer were associated with an independent risk for mortality (RR: 2.1[1.3-4.2], p=0.001), need for mechanical ventilation (RR: 3.8[2.4-11.3], p=0.0001), admission in intensive care unit ICU (RR : 1.9[1.2-8.4], p=0.02), and prolonged duration of hospitalization (RR: 3.1[2.2-9.9], p=0.0001). In addition, elevated levels of PCT were associated with an independent risk for mortality (RR: 4.1[1.1-12.5], p=0.0001), need for mechanical ventilation (RR: 3.02[1.4-9.8], p=.0001), admission in intensive care unit ICU (RR : 2.2[0.9-7.2], p:0.004), and longer duration of hospitalization (RR: 3.8[1.9-11.3], p=0.0001). Conclusion: The current study demonstrated poor results of elevated levels of PCT and D-dimer on final outcome regarding morbidity and mortality in COVID-19 patients especially PCT levels.

Keywords: COVID-19, PCT, D-dimer, outcome.

[Full Text Article]




    December issue has been successfully launched on December 2023.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia