ROLE OF ASPIRIN IN CATARACT
Syed Ehtaishamul Haque*
Role of aspirin in cataract is continuously being investigated. Epidemiological studies indicated that regular use of aspirin and aspirin like analgesics decrease the incidence of cataract. Laboratory studies offer several possible mechanisms by which aspirin exert its effect (A) via modification of glucose metabolism (B) via changes in physical behaviour of proteins within the lens fibers or (C) in the communication between lens epithelial cells. Disorder of each of these processes is associated with lens opacification and can be modified by aspirin. Aspirin is particularly appealing as anti-cataract drug because it has relatively few side effects and is inexpensive. However, various case studies indicated that aspirin has no role to play in cataract prevention rather it may cause cataract, which invoked a continuous debate regarding its role.
Keywords: Cataract, Aspirin, Post-translational modifications, Protein aggregation.
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