PHARMACOLOGICAL EVALUATION OF ANXIOLYTIC ACTIVITY OF FERONIA LIMONIA (WOOD APPLE) LEAVES EXTRACT IN EXPERIMENTAL ANIMAL

Rohit Jatav and Rekha Gour

ABSTRACT

Anxiety disorder is one of the most frequent mental illnesses that people suffer from. It is characterized by motor stress, sympathetic overactive and nervousness and surveillance syndromes. Aside from the few chemical therapies that are accessible, such as benzodiazepine and serotonin modulators, not much treatment options are at hand that safely and effectively alleviate anxiety. The anxiolytic activity of ethanolic extract of Feronia limonia leaves is evaluated with two validated modes, elevated plus maze and light and dark exploration test. A total of 30 animals (n = 30) were used. They were divided into five groups of six animals each for both models. The effects of the test crude drug Feronia limonia at three different doses 2.5, 4.5, and 6.5 mg/kg were compared with the standard anxiolytic diazepam at 1 mg/kg dose and control group using 1% gum acacia at 10 ml/kg dose 1 h after administration of the drug. Anti-anxiety was evaluated by using elevated plus maze (EPM) and light and dark model methods. In experimental mice, the ethanolic extract has anxiolytic properties. So it is supports the use of Feronia limonia as anxiolytic agents. Further research should be conducted to determine the active ingredient responsible for the anti-anxiety activity.

Keywords: Anxiety, anxiolytic, Ethanolic extract, Elevated plus maze, light and dark model, Feronia limonia.