EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND IN VITRO EVALUATION STUDIES ON ORAL DISINTEGRATING TABLETS OF BROMHEXINE HYDROCHLORIDE BY USING NATURAL SUPER DISINTEGRANTS

Guduri Suresh, V. Jhansi Priya Marabathuni* and Naidu Narapusetty

ABSTRACT

The present study is an attempt to select best possible combination of diluents and disintegrants to formulate dispersible tablet of BromhexineHcl which disintegrates within few minutes there by reducing the time of onset of action.Mannitol is selected as diluents, natural gums such as guar gum, Karaya gum were selected as super disintegrants. Microcrystalline cellulose was used in all formulations. Aspartame as a sweetening agent, Magnesium stearate as a Lubricant.Guar gum is used as the super disintegrant in the formulation F1 – F3 at the concentrations of the 6, 10, 18 % respectively.Karaya gum is used as the super disintegrant in the formulation F4 – F6 at the concentrations of 6, 10, 18 % respectively.Direct Compression method was used to formulate the tablets.All the formulations were showed the acceptable values were found to be within the IP limits for precoprssed parameters .The percentage Drug content of all tablets was found to be between 98.3% - 102.2% of BromhexineHcl , which is within the limit.As the concentrations of the guar gum increases in the formulations F1 – F3 the disintegration time found to be decreased and the disintegration time for these formulations were 1.20, 1.09, 1.04 seconds respectively and the percentage drug release was also found to be increased for these formulations as 90.71, 94.97, and 98.21 % respectively. From the data obtained, it is observed from the formulation containing Guar gum - 18mg, Micro crystalline cellulose - 50mg in Formulation F3, shows Disintegration time in 1.04 mins and the Percentage drug release is of 98.21 % at the end of 30 min which satisfied all the tablet evaluation parameters for dispersible tablet. Hence looking at all the satisfactory parameters F3 batch is selected as the optimized batch.

Keywords: oro dispersable tablets, super disintegrants, natural polymers, Dinsintergration time.

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