EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF PROLONGED RELEASE BUCCAL PATCH OF SALBUTAMOL

Kunda Komali, V. Jhansi Priya Marabathuni* and Naidu Narapusetty

ABSTRACT

In ithe ipresent iwork isuccessful iattempt iwas imade ito iformulate iprolonged irelease iSalbutamol ibuccal ipatch iby solvent icasting imethod iusing ihydrophilic ipolymers iHPMC iK4M, iCarbopol i974P iand iPolyethylene iglycol i400 as iplasticizer. iThe idrug ipolymer icompatibility iwas iverified iby iFT-IR istudies. iThe istandard icurve iof Salbutamol iin ipH i6.8 iphosphate ibuffer iwas iprepared.Totally i9 itrial ibuccal ipatches iwere iprepared iand evaluated ifor iweight ivariation, ithickness, idrug icontent, ifolding iendurance, iswelling iproperty, isurface ipH, percent imoisture iloss, iex ivivo imucoadhesion itime, iin ivitro idissolution itest iand iex ivivo ipermeation istudy.It was iobserved ithat iincreasing ithe iHPMC iK4M iconcentration ihas ia isignificant iincrease iin imucoadhesion itime and idecrease iin idrug irelease. The ioptimized iformulation ishows isatisfactory iresults iin ithe iparameters isuch ias thickness, ihardness, idrug icontent, iswelling iindex, imucoadhesion itime, iin ivitro idissolution iand idiffusion studies. iIt ishows izero iorder idrug irelease iprofile idepending ion ithe iregression ivalue.

Keywords: Solvent icasting imethod, Trasdemral delivery system, In vitro studies, Optmised formulation.

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