FORMULATION AND EVALUATION OF TASTE MASKED AZITHROMYCIN SUSPENSION AND ITS COMPARATIVE EVALUATION WITH MARKETED SAMPLE

Katla Yedukondalu, V. Jhansi Priya Marabathuni* and Naidu Narapusetty

ABSTRACT

Azithromycin, the macrolide antibiotic, is an azalide derived from erythromycin having bactericidal and bacteriostatic activity by inhibiting the mRNA of the bacteria. It is characterized by its bitter taste which is intensified by the amide group which limits its use for children as the oral liquid form is the most favorable form. The taste can be masked by different techniques and materials of which is the ion-exchange resin, flavors and adsorbing agents. Several formulations were carried out by Drug-resin complexation method. It was concluded that the formulation S-7 was satisfactory than other formulations of S-1, S-2, S-3, S-4, S-5 & S-6. The formulations S-7 was compared with a leading brand of marketed sample and it was found to match with formulations S-7 in all aspects. The bitter taste was masked in formulations S-7 better than the marketed sample.

Keywords: Taste Making Suspension, Resins Macrolide Antibiotic.