FORMULATION DEVELOPMENT AND EVALUATION OF ORO-DISPERSIBLE TABLETS OF TERBUTALINE

Kuruva Naresh, *V. Jhansi Priya Marabathuni and Naidu Narapusetty

ABSTRACT

The present work was concluded that to develop a stable, safe, fast release and convenient Oro dispersible tablets of Terbutaline for rapid therapeutic action. The formulations were optimized by using design expert software all the Five formulations (F1 to F5) of Oro dispersible tablets of Terbutaline were successfully prepared using Sodium Starch Glycollate as a super disintegrants and crospovidone by direct compression method. The Formulations were evaluated for parameters like thickness, hardness, friability, in- vitro disintegration time, wetting time, water absorption ratio, and in- vitro drug release studies. Based on the % of drug release at 15 minutes shows F1 maximum of 86.8 % and 60 minutes the maximum release of 95.5 %. The formulation (F1) was subject to stability studies for 3 months by storing them at 30°C/65%RH, 35°C/70%RH and 40°C/75%RH. The Results of physical appearance, hardness, friability, disintegration test, and % drug release have shown that there was no significant change at different storage conditions.

Keywords: Oro dispersible tablets, terbutaline, stability, direct compression method.