FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF STABLE DOLASETRON HCL NANOSUSPENSION FOR IMPROVED DISSOLUTION

Dasari Poojitha, *V. Jhansi Priya Marabathuni and Naidu Narapusetty

ABSTRACT

The present work was formulation development and invitro evaluation of stable Dolasetron HCL nanosuspension. Four formulations were formulated with different stablizers and surfactants. Out of four formulations, the formulation with the stabilizer and surfactant that resulted in low value of particle size and PDI were selected for further optimization. (T1- PS 287.3 and PDI 0.385). The obtained particle size, PDI and zeta potential was found to be 228.2nm, 0.376 and - 7.8mv respectively. Invitro dissolution studies revealed that formulation F5 has uplifted drug release of 92.5% and 98.9% on 40 minutes at pH 1.2 and pH 6.8 respectively. The drug release kinetics optimized nanosuspension at pH 7.4 revealed that the formulations undergone First order / anamolus / non-fickian diffusion drug release. So it is evident that formulating into nanosuspension results in improved stability, solubility and rapid drug release.

Keywords: Nanosuspension, different stablizers and surfactants, kinetics, non-fickian diffusion.