EVALUATION OF ANALGESIC AND ANTI-ULCER ACTIVITY BY HERBAL PLANT EXTRACTS

Sravani Batchu*, G. Tulja Rani, B. Akhila, Ch. Tejaswini and Isha Sharma

ABSTRACT

The unrivalled substitute to synthetic medicines, available, for relieving, pain and ulcers, are found in natural products of plants. They are known to exhibit a variety of activities. The objective of the present study is screening of M. piperita & M. Charantia for their analgesic and anti-ulcer activity. The extract of leaves of M. piperita & M. Charantia were tested in the Eddy’s hot plate method and in pyloric ligation. The treatment of M. piperita & M. Charantia at dose 200mg/kg for analgesic activity reduced the pain induced by the Hot Plate method and the potency was found to be equivalent as compared to standard drug Aspirin. The treatment of M. piperita & M. Charantia at dose 500mg/kg reduced the formation of ulcers induced by the pyloric ligation method and the potency was found to be equivalent to the standard drug Ranitidine. The presence of alkaloids, tannins and flavonoids may be accountable for the analgesic and anti-ulcerative activity of M. piperita and M. charantia. The results further suggest that M. piperita and M. charantia possess analgesic and anti-ulcer activities.

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