EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OF COLOCASIA ESCULENTA STEMS BARK ON EXPERIMENTAL ANIMALS

Mohd Nadeem*, Praveen Kumar, Dr. Nasiruddin Ahmad Farooqui

ABSTRACT

This study looked at the anti-inflammatory properties of an aqueous extract of Colocasia esculenta stem bark. An aqueous extract of Colocasia esculenta stem bark stem bark stem bark was tested for anti-inflammatory properties using four in vitro assays: albumin denaturation inhibition, membrane stabilization examination, testing of membrane sustaining activity, radiation heat induced algesia, and carrageenan-induced rat paw edema. The results revealed that orally administering Colocasia esculenta stem bark stem bark at two dosages of 200 mg/kg and 400 mg/kg to the experimental mice considerably [(p<0.05), (p<0.01)] reduced foot edema when compared to the control-group ( thirty minutes before the carrageenan administration). The use of Colocasia esculenta stem bark stem bark at a dose of 200 milligrams significantly reduced paw swelling with 66.51% after three hours of treatment and 70.94% after 5 hours, based on our research. Indomethacin caused a decrease of 78.72% and 83.33% after 3h and 5h, respectively, whereas Colocasia esculenta stem bark stem bark at 400mg/kg produced a reduction of 74.40% and 81.98%. Finally, the outcomes indicated that all of the examined leaves have anti-inflammatory properties at varying degrees, which might be attributable to changes in the content and concentration of bioactive chemicals.

Keywords: Colocasia esculenta stem bark stem bark team bark, anti-inflammatory activity, aqueous extract, Carrageenan-induced rat paw edema etc.