FORMULATION, DEVELOPMENT AND EVALUATION OF FAMOTIDINE ORODISPERSIBLE TABLETS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman and Tawfeek A. A. Yahya

ABSTRACT

The objective of the present study was to prepare Famotidine as Orodispersible tablets. Orodispersible tablets dissolve rapidly and show higher bioavailability than conventional tablets. Stomach acidity symptoms are treated by many effective drugs; however, they are slow to produce the desirable effect. Therefore, to decrease the patient time in suffering of these symptoms, Orodispersible drug-delivery system significantly increased patient acceptance by virtue of rapid disintegration, self-administration without water and finally improved patient compliance. Famotidine is selective H2 receptor blocker, used in treat duodenal ulcer condition and heartburn. The drug absorbed slowly and incompletely from GIT, bioavailability 40% and onset of action is less than 1hr (Initial; 1hr – 4hr (peak), in order to improve onset of action and increase bioavailability Famotidine was developed as Orodispersible tablets. Tablets were prepared by wet granulation and direct compression methods using sodium starch glycolate and croscarmellose sodium and crospovidone as superdisintegrants. The tablets were evaluated for weight variation, thickness, diameter, hardness, friability, wetting time, in-vitro dispersion time, in-vitro disintegration time, assay and in-vitro dissolution study. Hardness and friability data indicated good mechanical strength of tablets. The results of in-vitro disintegration time of F4 and F6 indicated that the tablets dispersed rapidly in mouth within 23.97, 10 seconds and 106.48%, 92.82% of the drug release within 5 minutes respectively. It was concluded that F4 and F6 are the best formulations of Famotidine Orodispersible tablets in order to increase onset of action and bioavailability of drug.

Keywords: Famotidine, Orodispersible tablets, Superdisintegrants, Drug delivery systems.