CYTOGENETIC ANALYSIS OF CHILDREN DOWN SYNDROME PATIENTS IN WASIT

Dr. Sada Jasim Abdulameer*

ABSTRACT

Background: Trisomy 21 or Down syndrome(DS) is the most common type of autosomal chromosome abnormality. Objective: The present study is aimed to document the types of cytogenetic abnormality in DS children and their relation to maternal age in Wasit. Method: Cytogenetic study was done for 30 cases who presented with Down syndrome (DS). It was done in a private lab. Cells were studied using lymphocyte culture technique arrested at G-metaphase. Results: Among the 30 cases of Down syndrome presenting aged from 1 day to 14 years, free trisomy 21 was present in 28 cases (93.3%). two cases were mosaics(6.7%). The median maternal age of the Wasit mothers at the birth of the affected child was 36 years. Conclusions: The identification of specific types of chromosomal abnormalities in Down syndrome children is important. It also help in setting priorities of cytogenetic screening individual cases.

Keywords: cytogenetic analysis, Down syndrome, karyotype pattern.