A REVIEW ON BIOLOGICAL ACTIVITY OF CHALCONE DERIVATIVES

Rashmi T., Kuldeep M. G.*, Kavya M. K., Harsha K. M., Rameef K. M. and Muhammed Arafad K. K.

ABSTRACT

Chalcones are a class of organic compounds characterized by their simple versatile chemical structure, consisting of two aromatic rings connected by a three-carbon (α, β-unsaturated carbonyl system). These compounds have significant attention due to their diverse range of biological activities and potential applications in medicinal and agricultural fields. The distinctive structure of chalcones allows for modification leading to the synthesis of various derivatives with different properties. Chalcones exhibit a wide spectrum of biological effects, including antioxidant, anti-inflammatory, anticancer, antimicrobial, and antidiabetic activities. Their mechanisms of action often involve interactions with key cellular targets such as enzymes and receptors leading to modulation of various signaling pathways. These properties have prompted extensive research into developing chalcones as lead compounds for drug discovery and development. In the agricultural sector chalcones and their derivatives have demonstrated potential as natural pesticides and plant growth regulators. Their ability to disrupt insect growth and inhibit fungal pathogens makes them as eco-friendly pest management strategies. In conclusion chalcones represent a fascinating class of compounds with a myriad of biological activities and potential applications. And it is significance in both medicinal and agricultural area.

Keywords: Chalcones, Biological activity, Anticancer, Antimicrobial activities, Drug discovery.