DEVELOPMENT & CHARACTERIZATION OF BILAYER IMMEDIATE AND SUSTAINED RELEASE TABLETSOF ATORVASTATIN CALCIUM AND NICOTINICACID

Jaylakshmi J.*, Thaila R., Muthukumar M., Kesavan M. and Senthilraja M.

ABSTRACT

The significance of controlled drug delivery systems has grown substantially in recent times, with bilayer tablets emerging as a prominent example. These tablets combine two distinct ingredients to create a dual-layered structure, enabling both immediate and sustained release of drugs. This innovative design not only addresses issues of drug incompatibility but also facilitates a gradual and consistent release of active pharmaceutical compounds in a sigmoidal pattern over an extended period. This approach ensures the maintenance of optimal plasma drug concentrations, often surpassing the maximum effective levels, for a prolonged duration. By curbing drastic dosage fluctuations commonly observed in traditional dosage forms, bilayer tablets offer a stable therapeutic outcome. Moreover, they enhance patient compliance by reducing dosing frequency. Additionally, these tablets prove advantageous by effectively treating multiple ailments in a single patient, thereby offering a holistic solution to co-morbid conditions through a singular medication format.

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