EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

BIOAVAILABILITY AND BIOEQUIVALENCE IN DRUG DEVELOPMENT: CURRENT INSIGHTS AND FUTURE PERSPECTIVES

Loukik Kumar Madipalli*

ABSTRACT

Bioavailability and bioequivalence are pivotal concepts in pharmaceutical research, playing a crucial role in ensuring the safety, efficacy, and interchangeability of drug products. This paper presents a comprehensive review of the current insights and future perspectives surrounding bioavailability and bioequivalence in the context of drug development. The introduction provides a foundational understanding of these concepts, elucidating the significance of bioavailability as a determinant of drug action and the critical role of bioequivalence in evaluating generic drug products. Factors influencing bioavailability, encompassing physiological, formulation-related, and administration route variations, are thoroughly examined. The methods employed to assess bioavailability, both in vitro and in vivo, are explored, with a focus on key pharmacokinetic parameters. Advancements in biopharmaceutical modeling, simulation, and biorelevant dissolution testing are presented as emerging trends with the potential to refine bioavailability predictions. The incorporation of physiologically-based pharmacokinetic modeling is showcased as a promising approach to enhance bioavailability estimation. This review paper encapsulates the current state of knowledge regarding bioavailability and bioequivalence in drug development. It emphasizes the dynamic nature of these concepts, highlighting the ever-evolving methodologies, regulations, and technologies that shape their application. The insights presented herein provide a foundation for researchers, clinicians, regulators, and industry stakeholders to navigate the intricate landscape of bioavailability and bioequivalence, driving the field toward safer, more effective, and innovative drug development practices in the future.

Keywords: Bioavailability, Bioequivalence, Drug development, Pharmacokinetics, Generic drugs, Regulatory guidelines, Biopharmaceutical modeling.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database