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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Amrane Mounira, Boussouf Khaira, Attalah Salah, Chekour Mouhamed Chahine, Touabti Abdelrezek


Cerebral vascular accidents constitute a public health problem and a cause of mortality and morbidity over the world. The hyperhomocysteinemia is an independent atherothrombotic risk factor for stroke. The B12 vitamin and folic acid are important determinants in homocysteinaemia levels. Our objective is evaluated the presence and / or absence of the association of hyperhomocysteinemia as well as vitamin B12 and vitamin B9 in cerebral vascular accidents in a population of the town of Setif, Algeria. This is a transversal study that includes 60 stroke patients hospitalized at the pavilion in vascular neurology emergencies and 60 controls. The blood in these patients was taking in 24-48 hours after cerebrovascular accident diagnosed by angiography scanner. We have dosing the homocysteine, vitamin B12, B9, total cholesterol, LDL and HDL, glucose, creatinine, creatinine clearance, uric acid, CRP, ferritenemie and researched other risk factors including diabetes, hypertension, smoking, obesity and metabolic syndrome according to the criteria of ATPIII. SPSS18 statistical analysis: The average homocysteinaemia in patients is significantly elevated compared to controls (14.14 ± 5.83μmol / l vs. 9.97 ± 2.57μmol / l). Hyperhomocysteinemia is correlated to vitamin B12 deficiency; 52.63% which presents a B12 deficiency and decreased vitamin B9. Stroke (AVC) in our patient was correlated with metabolic syndrome and the hyperhomocysteinemia, hyperglycemia and deterioration of renal function. Conclusion: The high frequency of deficiencies in Group B vitamins in our patients associated to the hyperhomocysteinemia found in diabetes obliges us to take charge emergency these deficiencies in the dietary plan as well as the therapeutic level.

Keywords: Cerebral Ischemic Stroke, homocysteine, vitamin B12, vitamin B9.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database