HEPATOPROTECTIVE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CALYCOPTERIS FLORIBUNDA ON CLOPIDOGREL INDUCED HEPATOTOXICITY – A REVIEW STUDY

*Sreenu Thalla, Polimera Chaitanya Sai, Gummadi Sita Ramaiah, Bhairapuneni Krishna Kanth, Sirigiri Puneeth Chowdary, Vishnumolakala Venkateswara Rao and Rama Rao Nadendla

ABSTRACT

Drug-induced hepatotoxicity poses a significant challenge in modern medical practice, prompting the search for natural remedies with hepatoprotective potential. Clopidogrel, a widely utilized antiplatelet medication, has been linked to hepatotoxic effects, necessitating the exploration of herbal interventions to mitigate such adverse reactions. This study aims to evaluate the hepatoprotective efficacy of the hydroalcoholic extract of Calycopteris floribunda against clopidogrel-induced hepatotoxicity using an experimental model. Histopathological observations corroborated the biochemical findings, revealing decreased hepatocellular damage and inflammatory infiltration in the extract-treated groups. These results indicate that the hydroalcoholic extract of Calycopteris floribunda holds promise as a hepatoprotective agent against clopidogrel-induced hepatotoxicity. The observed effects may be attributed to the extract's phytoconstituents with antioxidant and anti-inflammatory properties. Further investigations are essential to elucidate the underlying mechanisms responsible for these hepatoprotective effects and to establish the extract's potential as a supplementary therapy for individuals receiving clopidogrel treatment.

Keywords: Calycopteris floribunda, hepatoprotective, hepatotoxicity, Clopidogrel.