EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE EVALUATION OF THE DIAGNOSTIC ACCURACIES OF THREE RAPID MALARIA TESTING KITS

Ifeanyi T. Nzekwe*, Chukwuma O. Agubata, Samuel C. Umeigbo, Chigozie E. Utazi, Charles O. Esimone, Ifeanyi E. Okoye

ABSTRACT

The rapid testing kits used in malaria detection in Nigeria are deemed by some health professionals to have the same diagnostic efficiency as microscopy and some have advocated their use in non-invasive testing. This study aims at evaluating the comparative diagnostic efficiencies of three commercially available kits in relation to microscopy, using invasive and non-invasive methods. Matched blood and saliva from 50 symptomatic patients were tested for malaria using three rapid tests, with microscopy as gold standard. Data were analyzed using Cochran’s Q and McNemar’s tests. Out of the three brands tested, only one was in agreement with microscopy when blood was used as specimen, with the other two differing at 5% confidence interval. Saliva-based testing demonstrated high specificity, while blood-based testing demonstrated higher sensitivity and accuracy and there was no correlation with blood-based testing for all the three brands (p < 0.05). There were no statistical differences between the outcomes of saliva-based testing for the three tests (p > 0.05). Two-third of the RDTs tested were significantly inferior to thick smear microscopy, with blood used as test specimen. Also, testing with saliva gave significantly lower sensitivity than blood-based testing for each RDT. Rapid testing kits should not be solely used as confirmatory test for malaria and saliva should not be substituted for blood.

Keywords: Sensitivity, malaria, detection, rapid, infectious disease.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing