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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Asarudeen A.*, Chitra M. and Senthilkumar Natesan


This study's objective was to design and validate a new Ultra-High-Performance Liquid Chromatography (UHPLC) method for the simultaneous determination of Telmisartan and Metoprolol Succinate in tablet formulations. This method was developed with an emphasis on accuracy, reproducibility, and a lower relative standard deviation (RSD), compliant with International Council for Harmonization (ICH) guidelines for method validation. The method's precision was confirmed by the low percent relative standard deviation (%RSD) values, with Telmisartan and Metoprolol Succinate recording 0.49 and 0.59 respectively. This implies the high reliability of the assay and retention times across repeated measurements. System suitability parameters were evaluated to ensure the efficiency of the chromatographic system, indicated by a plate count greater than 2000. A tailing factor below 2 further reinforced the method's efficiency, suggesting symmetrical and well-shaped peaks. The robustness of the method was further underscored by its excellent linearity. The linearity equations for Telmisartan (y = 0.0298x - 0.0285) and Metoprolol Succinate (y = 0.0686x + 0.1282) both produced correlation coefficients (R²) close to 1, demonstrating excellent linearity in the relationship between concentration and peak area. The method's accuracy was established by calculating the mean percent recovery after performing triplicate injections at each level. The method achieved high mean percent recovery values for both Telmisartan (98.95% and 100.19%) and Metoprolol Succinate (99.68% and 100.21%). Finally, the method precision and intermediate precision were confirmed by the low %RSD values for both drugs (0.27% for Telmisartan and 0.23% for Metoprolol Succinate), which fell below the acceptable limit of 2. The robustness of the method was further corroborated when system suitability parameters remained unaffected despite variations in conditions. In conclusion, the newly developed UHPLC method provides an efficient, robust, and precise tool for the simultaneous estimation of Telmisartan and Metoprolol Succinate in tablet formulations. This facilitates accurate drug content assessments in routine quality control tests for pharmaceutical companies. This study makes a significant contribution to the evolution of pharmaceutical analytical techniques, offering valuable insights into the use of validated UHPLC methods.

Keywords: Telmisartan, Metoprolol succinate, UHPLC, Method Validation.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia