DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF OFLOXACIN AND METRONIDAZOLE BY SIMULTANEOUS EQUATION METHOD
H. I. Patel, S. K. Kamble*, K. B. Ghatge, T. S. Kapshe, S. S. Mali and P. B. Toraskar
ABSTRACT
The UV spectrophotometer has successfully accomplished simultaneous estimation. The simultaneous equation approach uses the creation and solution of simultaneous equations in mathematics. The suggested approaches are straightforward, quick, affordable, and accurate for routine simultaneous measurement of ofloxacin and mertronidazole, and they have been effectively used in pharmaceutical formulation without excipient influence. Utilising the USP II dissolution test apparatus, the simultaneous equation approach was successfully used to conduct a dissolution analysis of a commercial tablet formulation. The primary goal of this study is to provide a straightforward, affordable, and trustworthy UV spectroscopic approach for the regular measurement of ofloxacin and metronidazole in suspension dose form. There is no literature available for the simultaneous UV spectroscopic assessment of ofloxacin and metronidazole in suspension dose form. In order to simultaneously estimate ofloxacin and metronidazole in suspension formulation, a spectroscopic approach was created. The created technique was approved in accordance with ICH norms.
Keywords: Ofloxacin, Mertronidazole, Simultaneous equation, UV spectrophotometer.
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