FLOATING MICROSPHERES: A REVIEW
N. Prathibha* and P. Hyma
ABSTRACT
The complication with the oral drug delivery system is sustainable release and the retention of the drug in the gastrointestinal tract for release over a favourable or desirable timeline. moreover gastric emptying is one such a process that have several complex role in vivo systems which is unpredictable and not same all the time with respective drugs, so in order to avoid the variability an effort has been made to develop drug delivery system such as GRDDS(gastro retentive drug delivery system), FDDS(floating drug delivery systems)which do have greater absorptive window and high residence time in the GIT. sometimes the drug is not completely absorbed due to the emptying rate of the GIT having narrow absorption window for some drugs and moreover gastrointestinal tract physiology and transit time leads to irregular availability and lack of therapeutic effect or desired pharmacological action overall tackling all the problems. they are also advantageous than other dosage forms like the scenarios of minimization of fluctuations in drug concentrations in plasma due to sustain release, showing its effect over a prolong period, desired therapeutic effect and pharmacological action,low side effects, low dosage administration and useful for short half life of drugs and enables administration at low frequency leading to lower drug waste and also improves solubility of drugs finally they extent scope for innovative products due to there retention capacity.
Keywords: Narrow Absorption Window, Half-Life.
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