A SCIENTIFIC REVIEW ON NANOGEL FOR THE TREATMENT OF INFLAMMATION

Mohammad Ali and Pradeepa K. R.*

ABSTRACT

Nanogels based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. The pursuit of this review article is to concisely describe the recent development of Nanogel drug delivery system in terms of drug loading and swelling of drug from Nanogels. Nanogels have enabled enlargement of functionalized nanoparticles, which act as a drug carriers that can be loaded with drugs and other active material to be released in a controlled manner at specific site. Nanogel may be ready by many strategies just like the particle gelation, Inverse mini emulsion, Dispersion, Chemical cross linking, fabrication of biopolymers and so on. It can be characterized by SEM, DSC, FTIR, Drug content, Particle size, Zeta potential and drug efficiency. Further, it can be evaluated by in vitro drug release and in vivo study in suitable animal modelling. In this review article, we have focused on basic methodology of Nanogels, evaluation terms, their application in industries.

Keywords: Nanogel, advantages, disadvantages, release mechanism, classification, methods, evaluations, applications.