RECENT INNOVATIONS OF DELIVERY SYSTEMS FOR ANTIMICROBIAL SUSCEPTIBILITY STUDY OF CIPROFLOXACIN BIODEGRADABLE FORMULATIONS FOR POST OPERATIVE INFECTION PROPHYLAXIS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman and Randa Mohammed Saif

ABSTRACT

Staphylococcus Aureus is a pathogen that frequently causes postoperative infections. Systemic injection of antibiotics is an intrinsically poor method for achieving high local tissue drug concentrations because the circulatory system equally distributes medications throughout the entire body. In the present study was to determine how well the biodegradable, lipid-based antibiotic Ciprofloxacin tablet formulations combat the primary cause of postoperative infection. The molding technique was employed to produce recent innovation delivery system formulation tablets for Ciprofloxacin. The microbiological studies were carried out in a laminar flow condition, and Muller Hinton agar was used as a medium to replicate body tissue. Zones of inhibition for all Ciprofloxacin formulations were lower than those attained using standards. At p 0.05, every Ciprofloxacin formulation deviates significantly from the reference. Based on findings, the result was deemed satisfactory because it was within the acceptable quality control standards for antibiotics. In conclusion Staphylococcus Aureus is regarded susceptible to antimicrobial developed Ciprofloxacin formulations, so they could be used in the prevention of post-operative infection (POI).

Keywords: Ciprofloxacin, Delivery systems, Recent innovations, Formulations, Biodegradable lipid base tablets, Zone of Inhibition, Staphylococcus Aureus, Antimicrobial susceptibility.