EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

OCULAR MANIFESTATIONS IN A SAMPLE OF SYRIAN PATIENTS WITH RHEUMATOID ARTHRITIS; A CROSS SECTIONAL STUDY

Hashem Obaid Hassnah* and Dr. Maysoun Kudsi

ABSTRACT

Background: Rheumatoid arthritis is the most frequent systemic disease affecting the joints and other organs such as the eyes. We aimed to evaluate the frequency and characteristics of ocular manifestation in patients with rheumatoid arthritis. Methods: All the study subjects underwent complete ophthalmological examination involving visual acuity assessment, examination of anterior and posterior eye segments, Schirmer’s test, diameter and mobility of pupils, as well as eyeball mobility assessment of intraocular pressure. Demographics data, disease duration, age at diagnosis, treatment, ocular symptoms and history were registered. Results: The age of study group was 41.5±10 years.78.59% were females. Ocular manifestation was present in 31.14%. The most common manifestation of ocular injury was episcleritis (57.03%), while scleritis was diagnosed in 16.41%. The most affective factors that lead to the ocular manifestations were biological treatment, and diagnosis age. Discussion: The prevalence of ocular manifestation ranges between 39% and66%, and it is increased with the disease duration. The most common manifestation of ocular involvement was dry eye, episcleritis, and scleritis. Uveitis is rare, occurring as a complication of scleritis, and as a complication of anti‑TNF agents. Some studies showed that positive serum RF and ACPA significantly increased the risk of having more ocular manifestations, especially dry eyes. Studies experience that the ocular manifestations prevalence significantly more frequent among male patients, long disease duration and treatment with biologics and DMRADs. Conclusion: Ocular symptoms are relatively frequent complications of RA, and may result in irreversible changes in vision. Regular ophthalmological examinations are essential among RA patients.

Keywords: Background: Rheumatoid arthritis is the most frequent systemic disease affecting the joints and other organs such as the eyes. We aimed to evaluate the frequency and characteristics of ocular manifestation in patients with rheumatoid arthritis. Methods: A

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