EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF DICLOFENAC ORODISPERSIBLE TABLETS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman, Sami Ahmed Saeed and Mokhtar Abd-hafiz Al-Ghorafi

ABSTRACT

Diclofenac Free Acid was chosen to be the active pharmaceutical ingredient (API) in a Orodispersible tablets ODTs formulation, being a model of nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac Free Acid is widely used as an analgesic, and being so, the faster the effect, the better the dosage form. The present study was aimed to formulate, evaluate and optimized a tablet which disintegrates and Orodispersible to show a rapid onset of action. In the present study, attempt has been made to prepare ODTs of Diclofenac Free Acid using superdisintegrants like croscarmellose sodium, and/or crospovidone in different ratios by direct compression. The prepared batches of tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time and in-vitro drug release which tested in comparing with standard drug. Among the all formulations F4 formulation was found to be showed improved drug release characteristics.

Keywords: Orodispersible tablets, Diclofenac Free Acid, Anti-inflammatory drug, Superdisintegrants.

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