IMPORTANCE OF INHALABLE MICROPARTICLES FOR ANTI ASTHMA AND ITS METHOD OF PREPARATION

Pooja S.*, Mallamma T. and Prakash S. Goudanavar

ABSTRACT

The current study's objectives included maximizing microparticle properties, describing lung deposition, drug release, evaluating cytotoxicity, conducting in vitro and in vivo studies to determine their pharmacological effects, and evaluating inhalable microparticles carrying anti-asthmatic drugs for both specific and non-specific bronchial inflammatory asthma response. The pulmonary route results in systemic drug release, requires a lower dose, has rapid drug release, fewer first-pass hepatic metabolism and side effects. A synopsis of current developments in inhalable microparticles that have been documented in publications and patents released in the last few years has been offered as a consequence. Recent developments in inhaler technology and major problems in pulmonary drug administration have been briefly explored. Inhaling anti-inflammatory drugs is the most common treatment for inflammatory diseases of the airways, such as asthma. The shape, melting point, size distribution, drug content and drug entrapment %, flow property, in-vitro drug release, and comparative drug release tests with commercial dosage forms of the resulting microparticles were all evaluated. Inhalable microparticles created using a variety of techniques, including emulsion polymerization, dry coating, air suspension, spray drying, and spray freeze-drying.

Keywords: Anti-Asthma, Pulmonary drug delivery, Inhalable Microparticles, Mechanisms and preparation.