EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3 IN HYPOXIA-INDUCED VASCULAR DEVELOPMENT: A REVIEW

Obeagu, Emmanuel Ifeanyi*, Okoroiwu,I.L., Ijioma, Solomon Nnah, Daniel-Igwe,Gloria

ABSTRACT

Vascular development is controlled by two processes: vasculogenesis and angiogenesis.Vascular development is regulated by various growth factors especially the vascular endothelial growth factor (VEGF). Hypoxia stimulates vascular development.The most important cellular response to hypoxia is transcriptional activation of a number of genes.The protein products of thes genes,of which VEGF-A is one of the best characterised,regulate metabolic adaptation and cell survival as improve oxygenation through erythropoiesis and neovascularisation

Keywords: Hypoxia, Vascular Endothelia Growth Factor (VEGF), Vascular Development.


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SJIF Impact Factor: 7.065

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