FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF ZOLPIDEM TARTRATE IMMEDIATE RELEASE TABLETS
A. Yasodha, Avinash Dundigalla and M. Hariprasad*
ABSTRACT
The aim of the present study is to develop and evaluate the immediate release tablet of Zolpidem tartrate by direct compression method. The superdisintegrant Crospovidone, Croscarmellose sodium and Fenugreek were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F6 exhibit highest dissolution using Croscarmellose sodium showed faster drug release 99.18% over the period of 45min while disintegration time of the tablet was showed 15 sec comparison to other formulations of Zolpidem tartrate.
Keywords: Zolpidem tartrate, Crospovidone, Croscarmellose sodium, Fenugreek superdisintegrant and Immediate release tablet.
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