EXTRACTION, ISOLATION, SYNTHESIS, PURIFICATION, CHARACTERIZATION OF LAWSONE AND FORMULATION AND EVALUATION OF LAWSONE HAIR DYE GEL

Jain A., Fulmali S.* and Rajput Tanya

ABSTRACT

Here we state that the extraction, isolation of lawsone and synthesis, purification, characterisation of lawsone was carried out successfully. Lawsone hair dye gel is the hair colorant gel prepared and evaluated. Lawsone was extracted by methods like soxhlet extraction, maceration method and tommasi method and the practical yield was obtained up to 2-3 g. Lawsone was synthesize and identified of lawsone by using thin layer chromatography with butanol: ethyl acetate: acetic acid (7.5:2.5:0.1) was used as the mobile phase, Rf value was found to be 0.7. And further identification of lawsone by using UV-Visible spectroscopy, colorimetry and FTIR and LC-MS which gives the correct identification and detection molecular mass peak of lawsone at 174.10 was observed. Moreover preparation and evaluation of Lawsone hair dye gel for the parameter like colour, consistency, pH, viscosity, appearance, spreadability, washability, and skin irritation were studied and the results were found to be acceceptable limits.

Keywords: Extraction, Isolation. Characterisation, FTIR and LC-MS.