A REVIEW: PARKINSONISM AND ITS TREATMENT

Balasubramaniyam P. N.*, Sathishkumar A., Satheesh Kumar K., Mohanapriya K., Sai Sudha S. and Ahamed Mueen M.

ABSTRACT

There are a number of neurodegenerative diseases that have been associated with Parkinsonism. There are a wide variety of symptoms associated with Parkinsonism, including a slew of symptoms that may eventually lead to programmed cell death as a result of selective and progressive degeneration of dopaminergic neurons. It is unknown what causes parkinsonism; however, recent studies suggest that oxidative stress produces apoptosis, leading to mitochondrial defects and neuro-inflammation. There were many agents used in models of PD, like Oxidopamine, MPTP, rotenone, and neurotoxin etc., It has become more popular to use traditional Chinese medicine or conventional pharmacological ideas to treat Parkinson's disease (PD) in China in recent years. All herbal medications and herbal formulations were tested in vitro as well as in vivo on PD models. As per respective genera or pharmacological activity, relevant chemicals including herbal blends with anti-Parkinsonian properties were included. The plant species used to make these herbal remedies were from 18 families and 24 genera, including Acanthopanax, Alpinia as well as Astragalus. Anti-Parkinsonian drugs can be developed by using these herbal remedies. Clinical studies should pay more attention to species in such genera and families, as they may hold the most promise for further research. Further investigation is needed to determine the active components of herbal extracts and compatibility laws of herbal formulas.

Keywords: Parkinsonism Disease, Herbal drugs for parkinsonism, traditional medicine, oxidative stress.