PREVALENCE AND ANTIMICROBIAL RESISTANCE PATTERNS OF METHICILLIN RESISTANT STAPHYLOCOCCI IN VARIOUS CLINICAL SAMPLES AT A TERTIARY CARE CENTRE IN HYDERABAD

Dr. Chandra Lekha Penchala*, Dr. Madhurima K. and Dr. Sudha Rani V.

ABSTRACT

Background: Prevalence of MRSA and MRCONS has been constantly increasing over decades. This study has been done to compare prevalence of MRSA and MRCONS in various clinical samples and its isolation rates from various departments to frame an epidemiologic data helpful for empirical therapy. And also to compare MRSA and MRCONS antibiotic susceptibility patterns. Materials and Methods: Present study was undertaken at Department of Microbiology at Osmania General Hospital in south India from January 2020 to December 2022 all the clinical samples collected with aseptic precautions were processed as per standard protocol .All clinically significant staphylococcus isolates cultured were subjected to antimicrobial susceptibility testing as per CLSI guidelines. Screening for methicillin resistance was done by CLSI recommended cefoxitin disc (30ug) method. Results: The prevalence of MRSA according to our study was 63% and that of MRCONS is 71%. Highest isolation being from pus samples, and from surgical department. Conclusion: Regular surveillance of methicillin resistance and antibiogram formation is important to combat increasing prevalence.

Keywords: Methicillin resistant staphylococcus aureus, Methicillin resistant coagulase negative Staphylococci, Cefoxitin.