A REVIEW ON NANOPARTICULATE SYSTEM FOR NASAL DRUG DELIVERY

Shashikiran Y. H.* and Mamatha G. T.

ABSTRACT

Drug delivery through nasal route has attracted the interest of scientific community as it has been potentially explored as an alternative route for the administration of vaccines and biomolecules such as proteins, peptides and non-peptide drugs that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism. In addition it minimizes the lag time associated with oral drug delivery and offers, self-medication, patient comfort and patient compliance. Particulate systems like nanoparticles are used as a physical approach to vary and enhance the pharmacokinetic and pharmacodynamic properties of varied sorts of drug molecules. Delivery of drugs to the target site is accomplished by a colloidal drug delivery system mainly by using nanoparticles. In this review we have discussed advantages, limitations, anatomy of nose, mechanism of action and factor affecting the permeability of drugs or biomolecule through nasal mucosa of nasal drug delivery system in local delivery, systemic delivery of the Drug. In conclusion, nanoparticles are one of the convenient drug delivery systems, which can be of potential use in controlling and targeting nasal drug delivery.

Keywords: Intrasal drug delivery, advantages, limitations, nanoparticles preparation of nanoparticles etc.