FLOATING DRUG DELIVERY SYSTEM – AN OVERVIEW

*Ranjith Gowda T.N. and Krishna K.R. and Mohammad Ali

ABSTRACT

Oral route drug administration has been the most successful route used for controlled delivery of drugs. Controlled release of drug delivery system optimizes the biopharmaceutical, pharmacokinetic, pharmacodynamics, properties of drugs and to reduce the side effects and to designed to deliver the drug in such a way that the levels are maintained within the therapeutic window effective for a long period till the system continuous to deliver the drug at a particular rate. The aim of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with particular focus on the main floating mechanism to achieve gastric retention. This review includes the physiology, factors controlling gastric retention time, excipient variables influencing gastric retention, approaches to designing single-unit, hydro-dynamically balanced system and multi-unit floating structure, and aspects of their classification, formulation and evaluation are discussed in detail, and few applications of these systems.

Keywords: Floating drug delivery system, micro particles, Gastric empting, Hydrodynamicaly balance system etc.