EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

A REVIEW ON SOLUBILITY ENHANCEMENT TECHNIQUE BY MICROCRYSTALS

Venkatesh*, Theerthesh K.V., Tanuja A.J., Nagendra R. and Hanumanthachar Johsi

ABSTRACT

Poor aqueous solubility and bioavailability of drugs are the important factors affecting the absorption of drugs and consequently their therapeutic effectiveness. Reduction of particle size micro crystallization technique has new opportunities for poorly aqueous soluble drugs. The solubility problem can be solved by changing the crystal habit of a drug. The anti-solvent crystallization has been widely used for micro crystallization of drugs in the presence of polymers for increasing the dissolution rate of poorly aqueous soluble drugs. This review focusses on solubility enhancement of poorly soluble drugs by microcrystals technique.

Keywords: Microcrystals, Crystal Habit, Solubility, Enhancement, Bioavailability.

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