CLINICAL IMPLICATIONS OF PEGYLATION: ADVANTAGES AND OPPORTUNITIES IN RENAL ANEMIA
Jay Kumar Sharma*, Amit B. Jain, Sandesh Warudkar, Nilanj Dave and Alok Chaturvedi
ABSTRACT
Pegylation is a complex process which includes attachment of Polyethylene glycol chain to the target molecule giving it certain advantages in terms of Pharmacokinetics and Pharmacodynamics. Various molecules have been modified with this process rendering them more suitable for administration as well as increasing their therapeutic efficacy. Its usefulness in Chronic Kidney disease (CKD) has also been explored. Anemia is a common comorbidity associated with CKD. The commonest causes include Erythropoetin and iron deficiency. Therefore the management relies on iron supplementation and Erythropoesis stimulating agents (ESAs). There are various ESAs available including short and long acting, depending on their half lives. The long acting ESAs include Methoxy Polyethylene Glycol EPO (MPG-EPO), which is 3rd generation ESA. The half life of this ESA is prolonged by addition of polyethylene glycol chain which gives it certain advantages. This review discusses about the process of pegylation and how it has become helpful for the management of patients suffering from renal anemia.
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