FORMULATION AND EVALUATION OF ORAL SUSTAINED RELEASE MATRIX TABLETS OF GLICLAZIDE
Krishna K. R.*, Krupashree K. G., Parthiban S. and Balasubramanian T.
ABSTRACT
Sustained release matrix tablet of Gliclazide were prepared by direct compression method using Kollidon SR as a release retardant. carbopol, HPMC K15 LV and di-calcium phosphate are used as polymers in different concentration. Compatibility study was carried out by FT-IR. The prepared blends for matrix tablet were evaluated for their flow properties by measuring angle of repose, Carr’s compressibility index and Hausner’s ratio and also were evaluated for post-compression parameters such as hardness, friability, thickness, % weight variation, % drug content and in-vitro dissolution test.
Keywords: Sustained release; Matrix tablet; polymers; Gliclazide; FTIR studies; In-vitro drug release; Kollidon SR etc.
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