OPHTHALMIC MEDICATED GEL AS A DRUG DELIVERY SYSTEMS: A REVIEW

Nilesh Rajaram Mahajan*, Ajit B. Tuwar, Prashant B. Patil, Prof. Dr. R. S. Bacchav

ABSTRACT

The goal of ocular therapeutics is to achieve the optimal concentration of the drug at the site of action. This process is carried out mainly due to the precorneal loss, which can prevent the drug from being absorbed properly. In order to improve the effectiveness of the drug, in-situ gel-forming systems can be used. This procedure is very challenging and interesting to implement. The eye is resilient to foreign substances due to its various anatomical and physiological properties. Formulators have to be able to penetrate the protective barriers without causing tissue damage. The various physiological, anatomical, and biotechnological properties of the eye make it resilient to foreign substances. Formulators have to be cognizant of the fact that they have to go through protective barriers without damaging tissue. Ophthalmic Gel maximize contact time, reduce tear dilution, and inhibit nasolacrimal drainage to promote optimal medication absorption. The main drawback of gel is that it causes blurry vision; as a result, it should only be used at night or for treating the outer and corners of the eyelids. The use of suspension as an ocular delivery method is predicated on the idea that particles might stay in the conjunctival sac. Precorneal medication loss can be minimized by utilizing a diffusion-controlled, non-erodible polymeric insert to delay drainage. Due to its complicated administration, inserts main drawback is the lack of patient acceptance. The need for more effective ocular delivery systems is driven by the development of newer, more sensitive diagnostic techniques and treatment substances.

Keywords: Ophthalmic, In-situ Gel, polymeric, ocular.