IMPORTANCE OF FUROSEMIDE IN THE KIDNEY DISEASE – A REVIEW

K. N. Priyadharshini*, R. Rikana, V. T. Dhana Sai Sree, V. Dharani, R. D. Ponmudi, K. Tirumala Naik and M. Kishore Babu

ABSTRACT

Furosemide is a loop diuretic, which is mostly used in different stages of kidney disease, it has many clinical roles. This review summarises the importance of furosemide and it’s efficacy in kidney disease. It is a potent natriuretic drug, that inhibits the Na+-K+-2Cl co-transporter to decrease the extracellular fluid volume expansion in heart and kidney disease. In patients with Heart failure, kidney disease, Lung disease furosemide is used to maintain the liquid balance to prevent or reduce edema. In treatment of hypertension also, furosemide is used. Lasix is the mostly preferred brand of furosemide. It helps in reduction of absorbing more amount of salt in our body which is later passed by urine. It's diuretics effect is determined by the urinary concentrations. Furosemide is considered as proxy because of its good urinary response in severity of acute kidney injury and due to some residual renal action. In CKD volume and sodium overload is corrected by furosemide. In kidney furosemide is fastly and completely excreted. In uric acid levels also furosemide has important role.

Keywords: Furosemide, Loop diuretic, Acute kidney injury, Natriuretic drug, Edema, Chronic kidney disease.