A COMPREHENSIVE REVIEW ON GENE THERAPY

Ankit Singh Chauhan*, Ashwani Kumar and N. Trilochana

ABSTRACT

The Gene therapy became possible through the advances of genetics and bioengineering that enabled manipulating vectors for delivery of extrachromosomal material to focus on cells. The ability to form site-specific modifications to the human genome has been an objective in medicine since the popularity of the gene because the basic unit of heredity. Thus, gene therapy is known because the ability of genetic improvement through the correction of altered genes or site-specific modifications that focus on therapeutic treatment. One of the most focuses of this system is that the optimization of delivery vehicles that are mostly plasmids, nanostructured or viruses. The viruses are more often investigated thanks to their excellence of invading cells and inserting their genetic material. However, there's great concern regarding exacerbated immune responses and genome manipulation, especially in germ line cells. In vivo studies in in vegetative cell showed satisfactory results with approved protocols in clinical trials.

Keywords: Gene therapy, Genetic Vectors, Gene transfer, Herpes simplex viruses.