( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Alaa Mohamed Alkawas*, Maram Farouk Obeid and Sarah Hossam Fahmy


Background: The purpose of this research is to assess the antibacterial activity and cytotoxicity of modified nanobased antibiotics as root canal medicaments in vitro. Methods: Depending on the type of intracanal medicine used, the dentinal tubules of 85 root samples that were infected with Enterococcus faecalis were randomly allocated to one of 5 groups. A total of 1mg/ml, 0.1mg/ml of [double antibiotic paste (DAP)] or [modified triple antibiotic paste (mTAP)] in regular form, DAP or mTAP loaded nano particles using the [poly lactic-co-glycolic acid (PLGA)] as a nano carrier and PLGA nanoparticles (control) were inserted in the root canal for 1 week. Dentine shavings were obtained after treatment, and colony-forming units were measured. MTT assay was utilized to assess cytocompatibility against human lung fibroblastic cell line [WI-38] after 24 and 48 hours. The data were statistically analyzed (P < .05). Results: In terms of bacterial eradication, DAP or mTAP loaded nano PLGA performed much better than the regular form. The higher the concentration, the higher the antibacterial effect (1>0.1mg/ml). while it showed no significant difference regarding the antibacterial effect of Nano mTAP. All intracanal medicaments were cytotoxic when in full concentration but when diluted their cytotoxic effect decreased. All the drug loaded nano PLGA showed a higher cytotoxic effect than their regular forms. Conclusions: DAP or mTAP loaded nano PLGA are more effective against Enterococcus faecalis than their regular counterparts but were more cytotoxic at higher concentrations.

Keywords: Double antibiotic paste, Enterococcus faecalis, Nanoparticles, Modified triple antibiotic paste, Cytotoxicity.

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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 July 2024 Issue has been Published, Kindly check it on


    JULY 2024 issue has been successfully launched on JULY 2024.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia