ANTIGLYCATION AND ALDOSE REDUCTASE ACTIVITY OF SWIETENIA MAHAGONI LEAF EXTRACT
Naveen Y. P.*, Venugopal L J and Jyothi Bala Chauhan
ABSTRACT
Aldose reductase is a prime target enzyme for the control of retinopathic complications along with controlling
glycation of proteins in diabetic subjects. Swietenia mahagoni is a traditional medicinal plants used by folklore to
treat various disorders such as hypertension and diabetes. Swietenia mahagoni leaf methanol extract was assayed
for in-vitro aldose reductase inhibition and antiglycation properties. The extract showed 30% inhibition inhibition
on aldose reductase activity and 53.65±2.5% inhibition on glycation and the antiglycation property increased with
increase in glucose concentration. The anti-glycation potential was more than amino guanidine a standard used in
antiglycation agent.
Keywords: Swietenia mahagoni, antiglycation, retinopathy, diabetes, aldose reductase.
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