EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIGLYCATION AND ALDOSE REDUCTASE ACTIVITY OF SWIETENIA MAHAGONI LEAF EXTRACT

Naveen Y. P.*, Venugopal L J and Jyothi Bala Chauhan

ABSTRACT

Aldose reductase is a prime target enzyme for the control of retinopathic complications along with controlling
glycation of proteins in diabetic subjects. Swietenia mahagoni is a traditional medicinal plants used by folklore to
treat various disorders such as hypertension and diabetes. Swietenia mahagoni leaf methanol extract was assayed
for in-vitro aldose reductase inhibition and antiglycation properties. The extract showed 30% inhibition inhibition
on aldose reductase activity and 53.65±2.5% inhibition on glycation and the antiglycation property increased with
increase in glucose concentration. The anti-glycation potential was more than amino guanidine a standard used in
antiglycation agent.

Keywords: Swietenia mahagoni, antiglycation, retinopathy, diabetes, aldose reductase.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )